In a big win for lab animals, the US Senate has taken a powerful step toward ending the use of animals in drug testing with the unanimous passage of the FDA Modernization Act. This vote sends a clear message: our laws can evolve, and science no longer needs to rely on animal suffering to protect human health. Now, this critical bill must pass the House of Representatives so its promise can become reality. We especially thank Senator Cory Booker (D-NJ) for his leadership in advancing this legislation. Senator Booker has been at the forefront of efforts both to modernize federal law and to ensure the FDA follows through on implementing humane, 21st-century testing protocols that prioritize human-relevant science over animal suffering — a bipartisan effort that reflects both moral clarity and scientific urgency. Senators Eric Schmitt (R-MO), Rand Paul (R-KY), Angus King (I-ME), Sheldon Whitehouse (D-RI), John Kennedy (R-LA), Richard Blumenthal (D-CT), Ben Ray Luján (D-NM), and Roger Marshall (R-KS) joined him in leading on this bill. For decades, millions of animals — including dogs, monkeys, rabbits, and mice — have endured painful laboratory experiments, despite growing evidence that animal testing frequently fails to predict how drugs will affect people. At the same time, safer and more reliable alternatives — such as organ-on-a-chip technology, human cell-based testing, and advanced computer modeling — have continued to advance. By passing the FDA Modernization Act, the Senate recognized that these modern, human-relevant methods deserve a clear path forward. The bill removes outdated mandates that force companies to use animals even when better options exist, helping spare animals from needless suffering while supporting faster, more effective medical innovation. We are deeply grateful to the Senators who worked across party lines to make this progress possible. Your leadership reflects both compassion and courage — and it shows that bipartisan action for animals is not only possible, but powerful. As companion legislation waits for action in the House, we urge you to continue championing the bill’s passage and to encourage your colleagues to act without delay. Millions of animals are depending on Congress to finish what the Senate has started. Please add your name to thank Senators Booker, Schmitt, Paul, King, Whitehouse, Kennedy, Blumenthal, Luján, and Marshall for leading the way by co-sponsoring the FDA Modernization Act 3.0.